I was getting wrist pain so I decided to try out this mouse. It felt super awkward at first but after one to three days it became second nature and is very comfortable and my wrist pain went away.
If I could design this I would make the scroll wheel and left/right click buttons further forward so that my large hands could scroll and click while having a full grip. This was my initial upset with the mouse but now I don't even notice. I think I just moved my hand positioning to accommodate the positioning.